I've done assembly level programming , not extensively but I did it. There are tools out there Such as Masm and linker putout by Microsoft so the tools are out there, they really are.

Eventually all the code we write is or thse registers that's what the compliers do. In dot net and with the IDE the is a regular step that we don't see. It used to be that you would compile something and the output was an object module or modules. The module or modules were then linked with a linker. That's what you have to when doing assembler.

It's interesting to learn and I think it really enhances a programmer's understanding of the machine and what the machine is doing. Believe it or not, employers are looking for .Net people not who are assembly level programmers, but people who have an understanding of the machine at that level.